Acoustic studies of cefotaxime sodium in aqueous medium at different temperatures and at frequency 5 MHz under atmospheric pressure

Ultrasonic velocity (U) and density (ρ) measurements have been performed for the antibiotic Cefotaxime Sodium in aqueous solution at five temperatures: 20°C, 25°C, 30°C, 35°C, and 40°C. These experimental values were employed to compute several thermodynamic and acoustic parameters, including adiabatic compressibility (βₐ), change in adiabatic compressibility (Δβ), relative adiabatic compressibility (Δβ/β°), apparent molal volume (Φᵥ), apparent molal compressibility (Φₖ), and their respective limiting values, Φ°ᵥ and Φ°ₖ. The variation of these parameters with temperature and concentration was analyzed to explore the structure-making or structure-breaking behavior of Cefotaxime Sodium in aqueous medium. The findings provide valuable insights into solute–solvent interactions and the molecular characteristics of this β-lactam antibiotic under thermal perturbation.

@article{ijter2025212507287880,
  author = {K. P. Sarkar and Dhanashri Panchbhai},
  title = {Acoustic studies of cefotaxime sodium in aqueous medium at different temperatures and at frequency 5 MHz under atmospheric pressure},
  journal = {International Journal of Technology &  Emerging Research },
  year = {2025},
  volume = {1},
  number = {3},
  pages = {262-273},
  issn = {3068-109X},
  url = {https://www.ijter.org/article/212507287880/acoustic-studies-of-cefotaxime-sodium-in-aqueous-medium-at-different-temperatures-and-at-frequency-5-mhz-under-atmospheric-pressure},
  abstract = {Ultrasonic velocity (U) and density (ρ) measurements have been performed for the antibiotic Cefotaxime Sodium in aqueous solution at five temperatures: 20°C, 25°C, 30°C, 35°C, and 40°C. These experimental values were employed to compute several thermodynamic and acoustic parameters, including adiabatic compressibility (βₐ), change in adiabatic compressibility (Δβ), relative adiabatic compressibility (Δβ/β°), apparent molal volume (Φᵥ), apparent molal compressibility (Φₖ), and their respective limiting values, Φ°ᵥ and Φ°ₖ. The variation of these parameters with temperature and concentration was analyzed to explore the structure-making or structure-breaking behavior of Cefotaxime Sodium in aqueous medium. The findings provide valuable insights into solute–solvent interactions and the molecular characteristics of this β-lactam antibiotic under thermal perturbation.},
  keywords = {Ultrasonic velocity, Interferometer, Cefotaxime Sodium, adiabatic compressibility, apparent molal volume, Aqueous medium.},
  month = {Jul},
}

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.