Optimized Xception Deep Learning Model for Automated Skin Disease Classification in Scalable Healthcare Systems

Healthcare advances hinge on early and accurate disease detection, yet access to expert diagnostics remains uneven worldwide skin conditions, from benign rashes to malignant melanomas, affect millions and often go unrecognized until they progress to severe stages. Skin diseases manifest in diverse forms lesions, infections, and malignancies that demand precise differentiation to guide treatment and prevent complications. However, variability in lesion appearance, reliance on manual inspection, and limited specialist availability lead to misdiagnosis, delayed intervention, and increased healthcare burdens. Conventional methods such as dermoscopy and biopsy are time-consuming, subjective, and ill-suited to large-scale screening, underscoring the need for automated, scalable solutions. Deep learning excels at discerning complex patterns in medical images, offering rapid, objective analysis of skin lesions. To address these challenges, we propose a fine-tuned Xception model: leveraging ImageNet-pretrained depthwise separable convolutions, we unfreeze the final 30 layers for domain-specific feature refinement, integrate global average pooling and dropout to prevent overfitting, and employ the Adam optimizer with learning-rate scheduling and early stopping to ensure stable convergence. Trained on a balanced, augmented dataset of nine skin condition classes, our framework achieves 98.9 % overall accuracy, macro-average AUC of 0.997, and per-class F1-scores exceeding 0.98, while maintaining a compact 22 MB footprint for edge deployment. This approach not only delivers rapid, standardized diagnosis but also democratizes access to dermatological expertise, paving the way for broader adoption of AI in healthcare. It will help to grow a medical industry.

@article{ijter2025212510054529,
  author = {Geeta Rani and Sahul Goyal and Lalit Kumar Awasthi and Love Kumar},
  title = {Optimized Xception Deep Learning Model for Automated Skin Disease Classification in Scalable Healthcare Systems},
  journal = {International Journal of Technology &  Emerging Research },
  year = {2025},
  volume = {1},
  number = {6},
  pages = {26-43},
  doi =  {10.64823/ijter.2506003},
  issn = {3068-109X},
  url = {https://www.ijter.org/article/212510054529/optimized-xception-deep-learning-model-for-automated-skin-disease-classification-in-scalable-healthcare-systems},
  abstract = {Healthcare advances hinge on early and accurate disease detection, yet access to expert diagnostics remains uneven worldwide skin conditions, from benign rashes to malignant melanomas, affect millions and often go unrecognized until they progress to severe stages. Skin diseases manifest in diverse forms lesions, infections, and malignancies that demand precise differentiation to guide treatment and prevent complications. However, variability in lesion appearance, reliance on manual inspection, and limited specialist availability lead to misdiagnosis, delayed intervention, and increased healthcare burdens. Conventional methods such as dermoscopy and biopsy are time-consuming, subjective, and ill-suited to large-scale screening, underscoring the need for automated, scalable solutions. Deep learning excels at discerning complex patterns in medical images, offering rapid, objective analysis of skin lesions. To address these challenges, we propose a fine-tuned Xception model: leveraging ImageNet-pretrained depthwise separable convolutions, we unfreeze the final 30 layers for domain-specific feature refinement, integrate global average pooling and dropout to prevent overfitting, and employ the Adam optimizer with learning-rate scheduling and early stopping to ensure stable convergence. Trained on a balanced, augmented dataset of nine skin condition classes, our framework achieves 98.9 % overall accuracy, macro-average AUC of 0.997, and per-class F1-scores exceeding 0.98, while maintaining a compact 22 MB footprint for edge deployment. This approach not only delivers rapid, standardized diagnosis but also democratizes access to dermatological expertise, paving the way for broader adoption of AI in healthcare. It will help to grow a medical industry.},
  keywords = {Skin diseases, CNN, xception, computer vision},
  month = {Oct},
}

Copyright © 2025 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.